The GCKR Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population

Autor: Mauren Isfer Anghebem-Oliveira, Giseli Klassen, Emanuel Maltempi de Souza, Fabiane Gomes de Moraes Rego, Dayane Alberton, Susan Webber, Geraldo Picheth
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Microbiology (medical)
Adult
medicine.medical_specialty
endocrine system diseases
Genotype
Clinical Biochemistry
030209 endocrinology & metabolism
Polymorphism
Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Pregnancy
Risk Factors
Internal medicine
medicine
Immunology and Allergy
Glucose homeostasis
Humans
Genetic Predisposition to Disease
Allele frequency
Research Articles
Alleles
Genetic association
Adaptor Proteins
Signal Transducing
Glucokinase regulatory protein
biology
Biochemistry (medical)
Public Health
Environmental and Occupational Health
nutritional and metabolic diseases
Hematology
Odds ratio
medicine.disease
Gestational diabetes
Minor allele frequency
Medical Laboratory Technology
Diabetes
Gestational
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
biology.protein
Female
Gene polymorphism
Brazil
Popis: Background The glucokinase regulatory protein (GCKR) regulates the activity of the glucokinase (GCK), which plays a key role in glucose homeostasis. Genetic variants in GCK have been associated with diabetes and gestational diabetes (GDM). Due to the relationship between GCKRP and GCK, polymorphisms in GCKR are also candidates for genetic association with GDM. The aim of this study was to evaluate the association between the GCKR rs780094 polymorphism and GDM in a Brazilian population. Methods 252 unrelated Euro-Brazilian pregnant women were classified as control (healthy pregnant women, n = 125) and GDM (pregnant women with GDM, n = 127) age-matched groups. Clinical and anthropometric data were obtained from all subjects. The GCKR rs780094 polymorphism was genotyped using fluorescent probes (TaqMan®, code C_2862873_10). Results Both groups were in Hardy–Weinberg equilibrium. The GCKR rs780094 polymorphism was associated with GDM in codominant and dominant models (P = 0.022 and P = 0.010, respectively). The minor allele (T) frequency for the control group in the study was 38.4% (95% CI: 32–44%), similar to frequencies reported for other Caucasian populations. Conclusion Carriers of the C allele of rs780094 were 1.41 (odds ratio, 95% CI, 0.97–2.03) times more likely to develop GDM.
Databáze: OpenAIRE
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