Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA)
| Autor: | Benjamin J. Williams, Alain G. Bertoni, Youngkyoo Jung, Gregory L. Burke, Suzanne Craft, Timothy M. Hughes, Kiran Kumar Solingapuram Sai, Christopher T. Whitlow, Maryjo Cleveland, Samuel N. Lockhart, Chris L. Schaich, Stephen R. Rapp, Kathleen M. Hayden, Bonnie C. Sachs |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Epidemiology Neuroimaging Article Cellular and Molecular Neuroscience Cognition Developmental Neuroscience Risk Factors Internal medicine medicine Dementia Humans Cognitive Dysfunction Cognitive decline Framingham Risk Score medicine.diagnostic_test business.industry Health Policy Brain Magnetic resonance imaging medicine.disease Atherosclerosis Magnetic Resonance Imaging Cognitive test Psychiatry and Mental health Risk Estimate Cardiology Neurology (clinical) Geriatrics and Gerontology business Biomarkers |
| Zdroj: | Alzheimers Dement |
| ISSN: | 1552-5279 |
| Popis: | Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact late-life brain health. Methods We examined baseline VRFs, and cognitive testing and neuroimaging measures (β-amyloid [Aβ] PET, MRI) in a diverse longitudinal cohort (N = 159; 50% African-American, 50% White) from Wake Forest's Multi-Ethnic Study of Atherosclerosis Core. Results African-Americans exhibited greater baseline Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE), Framingham stroke risk profile (FSRP), and atherosclerotic cardiovascular disease risk estimate (ASCVD) scores than Whites. We observed no significant racial differences in Aβ positivity, cortical thickness, or white matter hyperintensity (WMH) volume. Higher baseline VRF scores were associated with lower cortical thickness and greater WMH volume, and FSRP and CAIDE were associated with Aβ. Aβ was cross-sectionally associated with cognition, and all imaging biomarkers were associated with greater 6-year cognitive decline. Discussion Results suggest the convergence of multiple vascular and Alzheimer's processes underlying neurodegeneration and cognitive decline. |
| Databáze: | OpenAIRE |
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