Inhibition of Virus Replication by RNA Interference
| Autor: | Ben Berkhout, Daniel Cupac, P.C. Joost Haasnoot |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genes
Viral viruses Endocrinology Diabetes and Metabolism Clinical Biochemistry Viral transformation Biology Dengue virus Virus Replication medicine.disease_cause Virus VP40 medicine Animals Humans Pharmacology (medical) Antibody-dependent enhancement RNA Small Interfering Molecular Biology Genetics Genetically modified virus Biochemistry (medical) Genetic Therapy Cell Biology General Medicine Virology Helper virus HIV-1 RNA Interference Oncovirus |
| Zdroj: | Journal of Biomedical Science. 10:607-616 |
| ISSN: | 1423-0127 1021-7770 |
| DOI: | 10.1159/000073526 |
| Popis: | RNA interference (RNAi) is a sequence-specific gene-silencing mechanism in eukaryotes, which is believed to function as a defence against viruses and transposons. Since its discovery, RNAi has been developed into a widely used technique for generating genetic knock-outs and for studying gene function by reverse genetics. Additionally, inhibition of virus replication by means of induced RNAi has now been reported for numerous viruses, including several important human pathogens such as human immunodeficiency virus type 1, hepatitis C virus, hepatitis B virus, dengue virus, poliovirus and influenza virus A. In this review, we will summarize the current data on RNAi-mediated inhibition of virus replication and discuss the possibilities for the development of RNAi-based antiviral therapeutics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|