Direct Photocontrol of Peptidomimetics: An Alternative to Oxygen‐Dependent Photodynamic Cancer Therapy
| Autor: | Viktoria V. Nikulina, Liudmyla V. Garmanchuk, Anne S. Ulrich, O I Dasyukevich, Sergii Afonin, Liudmyla Ostapchenko, Olha V. Storozhuk, D. Shelest, Sergey Zozulya, Oleg Babii, T. Nikolaienko, Igor V. Komarov, Volodymyr Iurchenko |
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| Rok vydání: | 2016 |
| Předmět: |
Peptidomimetic
Cell Survival medicine.medical_treatment chemistry.chemical_element Photodynamic therapy Peptide Antineoplastic Agents Photochemistry 010402 general chemistry Oxygen 01 natural sciences Catalysis Cell Line Mice Neoplasms medicine Animals Humans Photosensitizer Cytotoxicity Cell Proliferation chemistry.chemical_classification Reactive oxygen species Mice Inbred BALB C Photosensitizing Agents Molecular Structure 010405 organic chemistry General Chemistry Photosensitizing Agent General Medicine Photochemical Processes 0104 chemical sciences chemistry Photochemotherapy Biophysics Peptidomimetics Drug Screening Assays Antitumor |
| Zdroj: | Angewandte Chemie. 128:5583-5586 |
| ISSN: | 1521-3757 0044-8249 |
| DOI: | 10.1002/ange.201600506 |
| Popis: | Conventional photodynamic treatment strategies are based on the principle of activating molecular oxygen in situ by light, mediated by a photosensitizer, which leads to the generation of reactive oxygen species and thereby causes cell death. A diarylethene-derived peptidomimetic is presented that is suitable for photodynamic cancer therapy without any involvement of oxygen. This light-sensitive molecule is not a mediator but is itself the cytotoxic agent. As a derivative of the cyclic amphiphilic peptide gramicidin S, the peptidomimetic exists in two thermally stable photoforms that are interconvertible by light of different wavelengths. The isomer generated by visible light shows much stronger toxicity against tumor cells than the UV-generated isomer. First in vivo applications are demonstrated on a tumor animal model to illustrate how the peptidomimetic can be administered in the less toxic form and then activated locally in a solid tumor by visible light. |
| Databáze: | OpenAIRE |
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