Diaporthichalasin, a novel CYP3A4 inhibitor from an endophytic Diaporthe sp

Autor:	Nongnuch Muangsin, Nongluksna Sriubolmas, Nattaya Ngamrojnavanich, Surachai Pornpakakul, Narongsak Chaichit, Amorn Petsom, Sophon Roengsumran, Suchon Deechangvipart, Tomihisa Ohta
Rok vydání:	2007
Předmět:	Diaporthe sp Pycnidione Stereochemistry Chemistry Organic Chemistry Drug Discovery Diaporthichalasin General Medicine Endophytic fungus CYP3A4 Inhibitor Spectral data Biochemistry IC50
Zdroj:	Tetrahedron Letters. 48:651-655
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2006.11.102
Popis:	A novel CYP3A4 inhibitor, diaporthichalasin, together with pycnidione were isolated from an endophytic fungus, Diaporthe sp. Their structures were elucidated on the basis of spectral data and the structure of diaporthichalasin was confirmed by X-ray crystallographic analysis. Diaporthichalasin exhibited significantly potent inhibition of CYP3A4 with an IC50 value of 0.626 μM, while the IC50 value of pycnidione was 465 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a414a0a15b2684bbbde109863cb1cf https://doi.org/10.1016/j.tetlet.2006.11.102 Zobrazit plný text záznamu Full Text from ScienceDirect