Plasma fluoride level as a predictor of voriconazole-induced periostitis in patients with skeletal pain
| Autor: | Erica L. Scheller, Lisa Kerr, Woo J. Moon, Anupam Suneja, Varsha Moudgal, David M. Vandenberg, Anurag N. Malani, Jacob A. Livermore, Eric Ferguson |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Pain Gastroenterology Methylprednisolone Fluorides Periostitis Internal medicine medicine Humans Whole Body Imaging Bone pain Adverse effect Articles and Commentaries Aged Retrospective Studies Voriconazole Aged 80 and over business.industry Methylprednisolone acetate Middle Aged medicine.disease Alkaline Phosphatase Rash Surgery Discontinuation Infectious Diseases Female medicine.symptom business Drug Contamination medicine.drug |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 59(9) |
| ISSN: | 1537-6591 |
| Popis: | Background. Voriconazole is a triazole antifungal medication used for prophylaxis or to treat invasive fungalinfections. Inflammation of the periosteum resulting in skeletal pain, known as periostitis, is a reported side effectof long-term voriconazole therapy. The trifluorinated molecular structure of voriconazole suggests a possible linkbetween excess fluoride and periostitis, as elevated blood fluoride has been reported among patients with periostitiswho received voriconazole.Methods. Two hundred sixty-four patients from Michigan were impacted by the multistate outbreak of fungalinfections as a result of contaminated methylprednisolone injections. A retrospective study was conducted among195 patients who received voriconazole therapy at St Joseph Mercy Hospital during this outbreak. Twenty-eight pa-tients who received both bone scan and plasma fluoride measurements for skeletal pain were included in the stat-istical analyses. Increased tracer uptake on bone scan was considered positive for periostitis. The primary outcomemeasure was the correlation between plasma fluoride and bone scan results.Results. Bloodfluoride(P |
| Databáze: | OpenAIRE |
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