Trends in Antibiotic Susceptibility in Staphylococcus aureus in Boston, Massachusetts, from 2000 to 2014
| Autor: | Georgia K. Lagoudas, Mohamad R. Abdul Sater, Sanjat Kanjilal, Soohong Kim, Maile Thayer, Yonatan H. Grad, Paul C. Blainey |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biological Engineering, Blainey, Paul C, Lagoudas, Georgia K |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Methicillin-Resistant Staphylococcus aureus 0301 basic medicine Microbiology (medical) Staphylococcus aureus antibiotic resistance Epidemiology medicine.drug_class Antibiotics Microbial Sensitivity Tests MRSA genomic epidemiology medicine.disease_cause Staphylococcal infections Tertiary care Microbiology Tertiary Care Centers 03 medical and health sciences Antibiotic resistance Drug Resistance Bacterial medicine Humans Aged Retrospective Studies Molecular Epidemiology Molecular epidemiology business.industry Middle Aged Staphylococcal Infections medicine.disease Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents 3. Good health Penicillin 030104 developmental biology Female business Genome Bacterial Boston medicine.drug |
| Zdroj: | Prof. Blainey via Howard Silver Journal of Clinical Microbiology |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.01160-17 |
| Popis: | The rate of infection by methicillin-resistant Staphylococcus aureus (MRSA) has declined over the past decade, but it is unclear whether this represents a decline in S. aureus infections overall. To evaluate the trends in the annual rates of infection by S. aureus subtypes and mean antibiotic resistance, we conducted a 15-year retrospective observational study at two tertiary care institutions in Boston, MA, of 31,753 adult inpatients with S. aureus isolated from clinical specimens. We inferred the gain and loss of methicillin resistance through genome sequencing of 180 isolates from 2016. The annual rates of infection by S. aureus declined from 2003 to 2014 by 4.2% (2.7% to 5.6%), attributable to an annual decline in MRSA of 10.9% (9.3% to 12.6%). Penicillin-susceptible S. aureus (PSSA) increased by 6.1% (4.2% to 8.1%) annually, and rates of methicillin-susceptible penicillin-resistant S. aureus (MSSA) did not change. Resistance in S. aureus decreased from 2000 to 2014 by 0.8 antibiotics (0.7 to 0.8). Within common MRSA clonal complexes, 3/14 MSSA and 2/21 PSSA isolates arose from the loss of resistance-conferring genes. Overall, in two tertiary care institutions in Boston, MA, a decline in S. aureus infections has been accompanied by a shift toward increased antibiotic susceptibility. The rise in PSSA makes penicillin an increasingly viable treatment option. |
| Databáze: | OpenAIRE |
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