Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord
| Autor: | L. Marlier, C. Cerruti, Jean-Rene´ Teilhac, Alain Privat |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Serotonin Ketanserin Tetrahydronaphthalenes Central nervous system Iodocyanopindolol Motility Tritium Iodine Radioisotopes medicine Animals heterocyclic compounds Receptor Molecular Biology 8-Hydroxy-2-(di-n-propylamino)tetralin Chemistry organic chemicals musculoskeletal neural and ocular physiology General Neuroscience Rats Inbred Strains Anatomy musculoskeletal system Spinal cord Rats Nociception medicine.anatomical_structure Spinal Cord nervous system Pindolol Receptors Serotonin Autoradiography Serotonin Antagonists Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 550:15-23 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(91)90400-p |
| Popis: | The distribution of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord was investigated with quantitative autoradiography. Receptors were labeled respectively with [3H]serotonin (5-[3H]HT],8-hydroxy-2-[N-dipropylamino-3H]tetralin (8-OH-[3H]DPAT), [125I]iodocyanopindolol and [3H]ketanserin. It is shown that 5-HT1, 5-HT1A and 5-HT1B receptors are distributed within the spinal cord according to a rostro-caudal gradient. Both 5-HT1 and 5-HT1A receptors are mainly present in the dorsal horn and 5-HT1B is present throughout the spinal cord, exhibiting high densities in the caudal-most part of the dorsal in lamina X and in the sacral parasympathetic area. On the other hand, 5-HT2 receptors are shown mostly in the thoracic sympathetic area and in the thoracic ventral horn; the dorsal horn exhibits few 5-HT2 receptors. The differential involvement of 5-Ht through different receptors in nociception, autonomous nervous system control and motility are discussed. |
| Databáze: | OpenAIRE |
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