Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp. hominissuis
Autor: | Chie Nakajima, Olga Narvskaya, Shiomi Yoshida, Manabu Ato, Igor Mokrousov, Yasuhiko Suzuki, Noriko Nakanishi, Ken Osaki, Hirokazu Yano, Kentaro Arikawa, Yukiko Nishiuchi, Tomotada Iwamoto, Ichiro Nakagawa, Fumito Maruyama, Daria Starkova |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Swine 030106 microbiology homologous recombination Biology Genome NTM pulmonary disease Microbiology Evolution Molecular 03 medical and health sciences Operon Genetics Animals Humans Allele Gene Lung Ecology Evolution Behavior and Systematics Alleles Local adaptation Mycobacterium Infections Polymorphism Genetic Pan-genome Trehalose DCT genetic population structure biology.organism_classification Adaptation Physiological Sexual reproduction Mycobacterium intracellulare pan genome Homologous recombination Mycobacterium Mycobacterium avium Research Article |
Zdroj: | Genome Biology and Evolution |
ISSN: | 1759-6653 |
Popis: | Mycobacterium avium subsp. hominissuis (MAH) is one of the most common nontuberculous mycobacterial species responsible for chronic lung disease in humans. Despite increasing worldwide incidence, little is known about the genetic mechanisms behind the population evolution of MAH. To elucidate the local adaptation mechanisms of MAH, we assessed genetic population structure, the mutual homologous recombination, and gene content for 36 global MAH isolates, including 12 Japanese isolates sequenced in the present study. We identified five major MAH lineages and found that extensive mutual homologous recombination occurs among them. Two lineages (MahEastAsia1 and MahEastAsia2) were predominant in the Japanese isolates. We identified alleles unique to these two East Asian lineages in the loci responsible for trehalose biosynthesis (treS and mak) and in one mammalian cell entry operon, which presumably originated from as yet undiscovered mycobacterial lineages. Several genes and alleles unique to East Asian strains were located in the fragments introduced via recombination between East Asian lineages, suggesting implication of recombination in local adaptation. These patterns of MAH genomes are consistent with the signature of distribution conjugative transfer, a mode of sexual reproduction reported for other mycobacterial species. |
Databáze: | OpenAIRE |
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