Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery?

Autor:	Joseph D. Meyers, Richard S. Agnes, Yu Cheng, Clemens Burda, Ann-Marie Broome, James P. Basilion, Tennyson L. Doane, Malcolm E. Kenney
Rok vydání:	2011
Předmět:	Drug Indoles media_common.quotation_subject medicine.medical_treatment Brain tumor Metal Nanoparticles Nanotechnology Photodynamic therapy Nanoconjugates Isoindoles Article Biomaterials Mice Nanocapsules Glioma Cell Line Tumor medicine Animals Humans General Materials Science media_common Photosensitizing Agents Epidermal Growth Factor Chemistry Brain Neoplasms General Chemistry medicine.disease ErbB Receptors Treatment Outcome Targeted drug delivery Photochemotherapy Colloidal gold Nanoparticles for drug delivery to the brain Delayed-Action Preparations Cancer research Nanomedicine Gold Hydrophobic and Hydrophilic Interactions Biotechnology
Zdroj:	Small (Weinheim an der Bergstrasse, Germany). 7(16)
ISSN:	1613-6829
Popis:	EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13669e4d3c6b5a8d8c1fe999e7da7f82 https://pubmed.ncbi.nlm.nih.gov/21630446 Zobrazit plný text záznamu Plný text