In vitro snake venom detoxifying action of the leaf extract of Guiera senegalensis
| Autor: | M I Sule, A. K. Haruna, E. M. Abdurahman, M. S. Abubakar, U. U. Pateh, B. M. Jahun |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pharmacology Plants Medicinal Traditional medicine Antivenins Plant Extracts Antivenom Snake Bites Venom Pharmacognosy Biology biology.organism_classification complex mixtures Guiera senegalensis Lethal Dose 50 Plant Leaves Mice Echis carinatus Snake venom Drug Discovery Toxicity Animals Female Naja nigricollis Snake Venoms |
| Zdroj: | Journal of Ethnopharmacology. 69:253-257 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/s0378-8741(99)00128-2 |
| Popis: | The extract of the leaves of Guiera senegalensis was found to detoxify (in vitro) venom from two common northern Nigerian snake species, Echis carinatus and Naja nigricollis, in separate experiments. There was a remarkable reduction in the mortality of albino mice after intra-peritoneal (i.p.) administration of reconstituted venom incubated with the extract, when compared to those challenged with the venom only. The survival of the animals exposed to the venom incubated with the different concentrations of the extract was used as the in vitro detoxification parameter. |
| Databáze: | OpenAIRE |
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