Relationship between GLIM criteria and disease-specific symptoms and its impact on 5-year survival of esophageal cancer patients
| Autor: | Shigeru Lee, Daiki Habu, Genya Okada, Harushi Osugi, Yoshinari Matsumoto, Yasunori Matsuda |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Nutritional Status GLIM Esophageal Diseases Critical Care and Intensive Care Medicine Severity of Illness Index Risk Factors Internal medicine Odds Ratio medicine Humans Esophageal Obstruction Aged Proportional Hazards Models Randomized Controlled Trials as Topic Retrospective Studies Nutrition and Dietetics Proportional hazards model business.industry Malnutrition Hazard ratio Odds ratio Middle Aged Esophageal cancer Prognosis medicine.disease Survival Rate Logistic Models Nutrition Assessment Preoperative Period Female Deglutition Disorders business Cohort study |
| Zdroj: | Clinical Nutrition. 40:5072-5078 |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2021.08.008 |
| Popis: | Summary Background & aims Malnutrition is common in patients with esophageal cancer, which affects their prognosis. The global leadership initiative on malnutrition (GLIM) criteria was recently proposed as the world's first diagnostic criteria for malnutrition. However, the association between esophageal cancer patients and the GLIM criteria is unclear. The purpose of this study was to evaluate the percentage of patients diagnosed with malnutrition preoperatively using the GLIM criteria, assess the impact of disease-specific symptoms on the severity of malnutrition, and assess the prognostic relevance of GLIM defined malnutrition in patients with esophageal cancer. Methods This was a retrospective single-center cohort study. Preoperative nutritional status of patients with esophageal cancer hospitalized between June 2009 and July 2011 was evaluated according to the GLIM criteria. Factors related to severe malnutrition as per the GLIM criteria were analyzed using multivariable logistic regression analysis. The association between the severity of malnutrition based on the GLIM criteria and 5-year survival was assessed using a multivariable Cox proportional hazard model. Results Overall, 117 esophageal cancer patients were nutritionally assessed. The percentage of moderate malnutrition and severe malnutrition was 21% and 23%, respectively. Subjective dysphagia [odds ratio (OR): 7.39, 95% confidence interval (CI): 1.46–37.52] and subjective esophageal obstruction (OR: 10.49, 95% CI: 3.47–31.70) were independent risk factors for severe malnutrition. The hazard ratio (HR) for 5-year mortality tended to be higher for moderate malnutrition (HR: 2.12, 95% CI: 0.91–4.95); however, it was not significantly associated with either moderate malnutrition or severe malnutrition (HR: 1.30, 95% CI: 0.52–3.27). Cases that were censored during the follow-up period probably affected the survival results. Conclusion Subjective feelings of dysphagia and esophageal obstruction might be related to malnutrition severity in esophageal cancer patients. Malnutrition assessed by the GLIM criteria was not significantly associated with 5-year survival. |
| Databáze: | OpenAIRE |
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