Expression of NGF receptors in normal and pathological human thymus
| Autor: | E. Labouyrie, Dominique Carles, Jean-François Velly, Antoine de Mascarel, Pierre Dubus, Alexis Groppi, Marie Parrens, Jean-Philippe Merlio |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty animal structures Stromal cell Adolescent Thymoma Immunology Cell Receptors Nerve Growth Factor Thymus Gland Biology Receptor Nerve Growth Factor Fetus Western blot Reference Values Proto-Oncogene Proteins medicine Humans Immunology and Allergy Low-affinity nerve growth factor receptor Tissue Distribution Nerve Growth Factors RNA Messenger Receptor trkA Child Receptor Aged medicine.diagnostic_test Carcinoma Infant Receptor Protein-Tyrosine Kinases Thymus Neoplasms Middle Aged medicine.disease medicine.anatomical_structure Nerve growth factor nervous system Neurology Trk receptor Cancer research Female Thymus Hyperplasia Neurology (clinical) Thymus hyperplasia |
| Zdroj: | Journal of Neuroimmunology. 85:11-21 |
| ISSN: | 0165-5728 |
| Popis: | The expression of NGF receptors was investigated in normal human thymus and in thymic hyperplasias, thymomas and thymic carcinomas. By RT-PCR, we detected TrkAI transcripts encoding for the high-affinity NGF receptor. Western blot analysis showed the presence of both TrkA and p75 NGFR proteins. In normal thymuses, epithelial subcapsular and medullar cells were TrkA immunoreactive. Interdigitated medullar cells were stained for both TrkA and p75 NGFR . While epithelial cells of normal thymuses or benign thymomas exhibited a TrkA positive–p75 NGFR negative phenotype, a switch to a TrkA negative–p75 NGFR positive phenotype was observed in malignant epithelial cell tumours and was associated with cell proliferation-associated MIB1 expression. Our results argue for a local role of NGF and its receptors on thymic stromal cells both in normal and neoplastic conditions. |
| Databáze: | OpenAIRE |
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