Diagnostic variability in the histopathological assessment of advanced colorectal adenomas and early colorectal cancer in a screening population

Autor:	Isabelle Focke-Snieders, Jurriaan B. Tuynman, Lisanne J.H. Smits, Iris D. Nagtegaal, Gesina van Lijnschoten, Elisa Vink-Börger, Rachel S. van der Post, Nicole C.T. van Grieken
Přispěvatelé:	Surgery, CCA - Imaging and biomarkers, Amsterdam Gastroenterology Endocrinology Metabolism, Pathology
Rok vydání:	2022
Předmět:	Oncology Adenoma medicine.medical_specialty Histology Lymphovascular invasion Colorectal cancer Population Pathology and Forensic Medicine Diagnosis Differential Internal medicine Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] Medicine Humans education Expert Testimony Referral and Consultation Early Detection of Cancer Netherlands Observer Variation education.field_of_study Clinical pathology business.industry General Medicine medicine.disease Alternative treatment digestive system diseases Pathologists Dysplasia Adenocarcinoma business Colorectal Neoplasms
Zdroj:	Histopathology, 80, 790-798 Histopathology, 80, 5, pp. 790-798 Histopathology, 80(5), 790-798. Wiley-Blackwell Smits, L J H, Vink-Börger, E, van Lijnschoten, G, Focke-Snieders, I, van der Post, R S, Tuynman, J B, van Grieken, N C T & Nagtegaal, I D 2022, ' Diagnostic variability in the histopathological assessment of advanced colorectal adenomas and early colorectal cancer in a screening population ', Histopathology, vol. 80, no. 5, pp. 790-798 . https://doi.org/10.1111/his.14601
ISSN:	0309-0167
Popis:	Contains fulltext : 249895.pdf (Publisher’s version ) (Open Access) AIM: The aim of this study was to evaluate interobserver variability between individual pathologists and a panel of pathologists in the histopathological assessment of advanced colorectal neoplasms in the Dutch bowel cancer screening population. METHODS AND RESULTS: Histological slides of adenomas with high-grade dysplasia and early colorectal carcinomas (CRC) from 20 different laboratories were reviewed by the pathology panel of the Dutch bowel screening programme. Interobserver variability was reported by descriptive statistics. In addition, potential clinical consequences of discrepancies were evaluated. A total of 104 cases of adenomas with high-grade dysplasia and 83 early CRCs were reviewed. Discrepancies were observed in 41 of 104 (39.4%) adenoma cases, which potentially had clinical consequences in 16 (15.4%) cases. For CRC, discrepancies were shown in 44 of 83 cases (53.0%) and would have potentially led to alternative treatment strategies in 25 (30.1%) cases. Most frequently, discrepancies were observed in the assessment of lymphovascular invasion (23 of 73 cases, 31.5%). CONCLUSION: This study showed that considerable interobserver variability is present in the histopathological assessment of advanced colorectal neoplasia, which may impact upon treatment choices. Additional stains and education, as well as intercollegial consultation, might decrease this variability.
Databáze:	OpenAIRE
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