The Density of Interstitial Cells of Cajal Is Diminished in Choledochal Cysts
| Autor: | Mustafa Dalgıç, Feza M. Akgür, Oktay Ulusoy, Osman Zeki Karakuş, Erdener Özer, Guray Akturk, Oğuz Ateş, Gülce Hakgüder, Esra Gurlek Olgun, Mustafa Olguner |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Pathology Adolescent Physiology medicine.medical_treatment Cell Count Gastroenterology 03 medical and health sciences symbols.namesake 0302 clinical medicine Cholelithiasis Internal medicine medicine Extrahepatic biliary tract Humans Choledochal cysts Cholecystectomy Child Common Bile Duct Common bile duct business.industry Gallbladder Infant Hepatology medicine.disease Interstitial Cells of Cajal Immunohistochemistry Interstitial cell of Cajal Proto-Oncogene Proteins c-kit 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Case-Control Studies Child Preschool Choledochal Cyst symbols Female business |
| Zdroj: | Digestive diseases and sciences. 61(3) |
| ISSN: | 1573-2568 |
| Popis: | Interstitial cells of Cajal (ICC) have been shown to be present in the extrahepatic biliary tract of animals and humans. However, ICC distribution in choledochal cysts (CC) has not been investigated. A study was conducted to investigate the distribution of ICC in the extrahepatic biliary tract, including CC, in pediatric human specimens. The specimens were divided into two main groups as gallbladders and common bile ducts. Gallbladders were obtained from the cholelithiasis, CC operations and autopsies. Common bile ducts were obtained from autopsies. Tissues were stained using c-kit immunohistochemical staining. ICC were assessed semi-quantitatively by applying morphological criteria and were counted as the number of cells/0.24 mm2 in each area under light microscopy. A total of 35 gallbladders and 14 CC were obtained from operations. Ten gallbladders plus common bile ducts were obtained from autopsies. The mean numbers of ICC in the gallbladders of cholelithiasis and the gallbladders of CC were 12.2 ± 4.9 and 5.3 ± 1.2, respectively (p = 0.003). The mean numbers of ICC in the common bile ducts and CC were 9.8 ± 2.9 and 3.4 ± 1.4, respectively (p = 0.001). The scarcity of ICC in the extrahepatic biliary tract may be responsible for the etiopathogenesis of the CC. |
| Databáze: | OpenAIRE |
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