| Popis: |
The remote effects of acute poisoning with organophosphates (OPs) are poorly studied, and the experimental models used often disregard species-related traits. Here we compare two toxicological models, both with rats as the model animal and paraoxon (POX) as the model OP, which were applied to study the dynamics of biochemical indices over 3 months after acute poisoning. Blood plasma carboxylesterase (CE) was preliminary inhibited with paraoxon or 2-(o-crezyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide (CBDP). As was expected, the most sensitive biochemical index within the first hours and days after OP poisoning was blood acetylcholinesterase (AChE) activity: it decreased by almost an order of magnitude in all experimental animal groups 3 h after poisoning. Changes in the parameters of carbohydrate and fat metabolism (triglyceride, free fatty acid, d -3-hydroxybutyrate, cholesterol, and glycerol levels) were detected at different time points after poisoning. Significant changes in a number of biochemical markers were found in positive control relative to negative control rats. |
