Huangjinya Black Tea Alleviates Obesity and Insulin Resistance via Modulating Fecal Metabolome in High-Fat Diet-Fed Mice
| Autor: | Suo Chu, Jialin Xu, Yan Huo, Chunpeng Wan, Jie Zhao, Mingxi Li, Yi Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Adipose Tissue White Hyperlipidemias Diet High-Fat Camellia sinensis 03 medical and health sciences Feces Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Metabolome medicine Animals Obesity chemistry.chemical_classification Mice Inbred BALB C 030109 nutrition & dietetics Bile acid Tea Chemistry Insulin Fatty acid Metabolism medicine.disease Gastrointestinal Microbiome 030104 developmental biology Endocrinology Hyperglycemia Metabolic syndrome Insulin Resistance Food Science Biotechnology Polyunsaturated fatty acid |
| Zdroj: | Molecular nutritionfood research. 64(22) |
| ISSN: | 1613-4133 |
| Popis: | Scope Huangjinya is a light-sensitive tea mutant containing low levels of tea polyphenols. Currently, most studies focused on characteristics formation, free amino acid metabolism and phytochemical purification. The biological activity of Huangjinya black tea (HJBT) on metabolic syndrome regarding fecal metabolome modulation is unavailable and is studied herein. Methods and results High-fat diet (HFD)-fed mice are treated with HJBT for 9 weeks, various metabolic biomarkers and fecal metabolites are determined. HJBT reduces adipogenic and lipogenic gene expression, enhances lipolytic gene expression, decreases adipocyte expansion, and prevents the development of obesity. HJBT reduces lipogenic gene expression, increases fatty acid oxidation-related genes expression, which alleviates liver steatosis. HJBT enhances glucose/insulin tolerance, increases insulin/Akt signaling, attenuates hyperlipidemia and hyperglycemia, prevents the onset of insulin resistance. HJBT modulates bile acid metabolism, promotes secondary/primary bile acid ratio; increases short-chain fatty acids production, promotes saturated and polyunsaturated fatty acids content; reduces carnitines and phosphocholines, but increases myo-inositol content; decreases branched-chain and aromatic amino acids content; increases the metabolite content related to pentose phosphate pathway. Conclusion This study reported the association between fecal metabolome modulation and metabolism improvement due to HJBT administration, proposes HJBT as a dietary intervention for preventing obesity and metabolic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text