Nested Case‐Control Study Utilizing MID‐NET® on Thrombocytopenia Associated With Pegfilgrastim in Patients Treated With Antineoplastic Agents
| Autor: | Yoshiaki Uyama, Yukio Oniyama, Yuki Kubota, Chieko Ishiguro, Natsumi Kinoshita, Toyotaka Iguchi, Takashi Ando, Kazuhiro Kajiyama |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Databases Factual Filgrastim Antineoplastic Agents 030226 pharmacology & pharmacy Sensitivity and Specificity Article Polyethylene Glycols Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Colony-Stimulating Factors Japan Internal medicine Neoplasms Odds Ratio Medicine Humans Pharmacology (medical) Child Aged Pharmacology Aged 80 and over business.industry Platelet Count Research Infant Odds ratio Articles Pharmacoepidemiology Middle Aged Thrombocytopenia Confidence interval Lenograstim 030220 oncology & carcinogenesis Case-Control Studies Child Preschool Cohort Nested case-control study business Pegfilgrastim medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics |
| ISSN: | 1532-6535 0009-9236 |
| Popis: | Although several spontaneous case reports on the occurrence of thrombocytopenia in patients treated with human granulocyte colony-stimulating factor (G-CSF) preparations have been accumulated, its actual causality is still unclear. To investigate the association between G-CSF preparations (filgrastim, nartograstim, lenograstim, and pegfilgrastim) available in Japan and thrombocytopenia in patients treated with antineoplastic agents, a nested case-control study was conducted using the Medical Information Database NETwork (MID-NET®) with the cohort of the Japanese population taking antineoplastic agents between 2009 and 2018. A case of thrombocytopenia was defined as a patient who had decreased platelet counts ( |
| Databáze: | OpenAIRE |
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