Preclinical In Vivo Safety of Poly-Phosphorylated Superlubrication Vectors for the Treatment of Osteoarthritis

Autor:	Yuval Ramot, Oleg Dolkart, Michal Steiner, Sabrina Jahn, Ronit Goldberg, Orna Cacical, Yossi Lavie, Nati Ezov, Gabi Agar, Abraham Nyska
Rok vydání:	2022
Předmět:	Cartilage Articular Sheep Phosphorylcholine Cell Biology Toxicology Injections Intra-Articular Rats Pathology and Forensic Medicine Rats Sprague-Dawley Disease Models Animal Liposomes Osteoarthritis Animals Humans Molecular Biology
Zdroj:	Toxicologic Pathology. 50:787-792
ISSN:	1533-1601 0192-6233
DOI:	10.1177/01926233221105393
Popis:	Osteoarthritis (OA) can lead to a significant functional disability. Poly[2-(methacryloyloxy)ethyl phosphorylcholine] (pMPC) liposomes are a novel treatment modality for OA, intended to restore the natural lubrication properties of articular cartilage. Here, we report on two studies aimed to assess the local and systemic safety and toxicity of pMPCylated liposomes in comparison with physiological saline, in Sprague-Dawley (SD) rats and in sheep after a single intra-articular (IA) injection. The animals were sacrificed after 1 and 6 weeks (rats) and 3 and 6 weeks (sheep). No signs of toxicity or abnormal clinical findings were observed. Histopathological evaluation revealed no signs of reactivity or abnormal findings in the injected joints or in any other organs. In conclusion, a single IA injection of the pMPCylated liposomes demonstrated an excellent safety profile and did not result in local reactivity or systemic toxicity, thus supporting its further development for use in humans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cb7c6cd7c86880835055d6baf2a7e7 https://doi.org/10.1177/01926233221105393 Zobrazit plný text záznamu