The genetic origin of Klinefelter syndrome and its effect on spermatogenesis
| Autor: | Jacques C. Giltay, Sjoerd Repping, Merel C. Maiburg |
|---|---|
| Přispěvatelé: | ARD - Amsterdam Reproduction and Development, Center for Reproductive Medicine |
| Rok vydání: | 2012 |
| Předmět: |
Male
Infertility Pediatrics medicine.medical_specialty Reproductive Techniques Assisted Offspring medicine.medical_treatment Male infertility Klinefelter Syndrome Internal medicine Animals Humans Medicine Spermatogenesis Infertility Male Azoospermia Assisted reproductive technology business.industry Obstetrics and Gynecology medicine.disease Endocrinology Reproductive Medicine Chromosome abnormality Klinefelter syndrome business |
| Zdroj: | Fertility and sterility, 98(2), 253-260. Elsevier Inc. |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2012.06.019 |
| Popis: | Klinefelter syndrome is the most prevalent chromosome abnormality and genetic cause of azoospermia in males. The availability of assisted reproductive technology (ART) has allowed men with Klinefelter syndrome to father their own genetic offspring. When providing ART to men with Klinefelter syndrome, it is important to be able to counsel them properly on both the chance of finding sperm and the potential effects on their offspring. The aim of this review is twofold: [1] to describe the genetic etiology of Klinefelter syndrome and [2] to describe how spermatogenesis occurs in men with Klinefelter syndrome and the consequences this has for children born from men with Klinefelter syndrome. (Fertil Steril (R) 2012;98:253-60. (C) 2012 by American Society for Reproductive Medicine.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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