Regular Consumption of an Antioxidant-rich Juice Improves Oxidative Status and Causes Metabolome Changes in Healthy Adults
| Autor: | Miguel Ángel Martínez-Bartolomé, Jara Pérez-Jiménez, M. Elena Díaz-Rubio, Fulgencio Saura-Calixto, Inmaculada Álvarez |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Blood Glucose Male Antioxidant medicine.medical_treatment Blood Pressure Grape Ascorbic Acid Urine Antioxidants Pomegranate Beverages chemistry.chemical_compound Malondialdehyde Metabolome medicine Humans Metabolomics Vitis Food science Fruit juice Inflammation Lythraceae medicine.diagnostic_test Polyphenols Ascorbic acid Lipids Antioxidant capacity Oxidative Stress Blood pressure chemistry Chemistry (miscellaneous) Polyphenol Fruit Female Oxidative status Lipid profile Food Science |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1573-9104 0921-9668 |
| Popis: | An improvement in oxidative status is associated with a reduction in the incidence of several chronic diseases. However, daily intake of antioxidants in Western diets is decreasing. This study evaluates the effect of daily consumption of an antioxidant-rich juice (ARJ) on oxidative status, cardiovascular disease risk parameters, and untargeted plasma and urine metabolomes. Twenty-eight healthy young adults participated in an 8-week clinical trial by drinking 200 mL of ARJ (pomegranate and grape) daily. At the end of the study, the subjects showed a significant decrease (−29 %) in plasma lipid oxidation (malondialdehyde concentration), and a significant increase (+115 %) in plasma antioxidant capacity. Plasma and urine metabolomes were also significantly modified and some ions modified in urine were identified, including metabolites of polyphenols, ascorbic acid and biliary acids. No significant changes were observed in lipid profile, inflammation, blood pressure or glycaemia. These results show that incorporating antioxidant-rich beverages into common diets may improve oxidative status in healthy subjects. This research was supported by the Spanish Ministry of Science and Innovation (AGL2011-27741) |
| Databáze: | OpenAIRE |
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