A Novel Strategy for Creating an Antibacterial Surface Using a Highly Efficient Electrospray-Based Method for Silica Deposition
| Autor: | Odelia Levana, Soonkook Hong, Se Hyun Kim, Ji Hoon Jeong, Sung Sik Hur, Jin Woo Lee, Kye-Si Kwon, Yongsung Hwang |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Staphylococcus aureus
QH301-705.5 Surface Properties antibacterial surface Catalysis Bacterial Adhesion Article Inorganic Chemistry Escherichia coli anti-adhesive properties Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy hydrophobicity Bacteria Polyethylene Terephthalates Organic Chemistry General Medicine Silicon Dioxide Computer Science Applications Anti-Bacterial Agents Chemistry electrospray silica deposition |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 513 International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 23, Iss 513, p 513 (2022) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms23010513 |
| Popis: | Adhesion of bacteria on biomedical implant surfaces is a prerequisite for biofilm formation, which may increase the chances of infection and chronic inflammation. In this study, we employed a novel electrospray-based technique to develop an antibacterial surface by efficiently depositing silica homogeneously onto polyethylene terephthalate (PET) film to achieve hydrophobic and anti-adhesive properties. We evaluated its potential application in inhibiting bacterial adhesion using both Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) bacteria. These silica-deposited PET surfaces could provide hydrophobic surfaces with a water contact angle greater than 120° as well as increased surface roughness (root mean square roughness value of 82.50 ± 16.22 nm and average roughness value of 65.15 ± 15.26 nm) that could significantly reduce bacterial adhesion by approximately 66.30% and 64.09% for E. coli and S. aureus, respectively, compared with those on plain PET surfaces. Furthermore, we observed that silica-deposited PET surfaces showed no detrimental effects on cell viability in human dermal fibroblasts, as confirmed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide and live/dead assays. Taken together, such approaches that are easy to synthesize, cost effective, and efficient, and could provide innovative strategies for preventing bacterial adhesion on biomedical implant surfaces in the clinical setting. |
| Databáze: | OpenAIRE |
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