Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior
| Autor: | Koro Gotoh, Isao Katsuragi, Seiichi Chiba, Kansuke Fujiwara, Hisae Ando, Hironobu Yoshimatsu, Takayuki Masaki, Takanobu Shimasaki, Toshiie Sakata, Tetsuya Kakuma, Kimihiko Mitsutomi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Corticotropin-Releasing Hormone Histamine H1 receptor Biochemistry Rats Sprague-Dawley Eating Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Neurotrophic factors Internal medicine medicine Animals Receptors Histamine H1 Mice Knockout Brain-derived neurotrophic factor Chemistry Brain-Derived Neurotrophic Factor Body Weight Feeding Behavior Histidine decarboxylase Anorexia Rats Mice Inbred C57BL Endocrinology Ventromedial nucleus of the hypothalamus nervous system Ventromedial Hypothalamic Nucleus Hypothalamus Histamine H3 receptor hormones hormone substitutes and hormone antagonists Histamine |
| Zdroj: | Journal of Neurochemistry. 125:588-598 |
| ISSN: | 0022-3042 |
| DOI: | 10.1111/jnc.12213 |
| Popis: | Brain-derived neurotrophic factor (BDNF), corticotropin-releasing factor (CRF), and hypothalamic neuronal histamine are anorexigenic substances within the hypothalamus. This study examined the interactions among BDNF, CRF, and histamine during the regulation of feeding behavior in rodents. Food intake was measured after treatment with BDNF, α-fluoromethyl histidine (FMH; a specific suicide inhibitor of histidine decarboxylase that depletes hypothalamic neuronal histamine), or CRF antagonist. We measured food intake in wild-type mice and mice with targeted disruption of the histamine H1 receptor (H1KO mice) after central BDNF infusion. Furthermore, we investigated CRF content and histamine turnover in the hypothalamus after BDNF treatment, and conversely, BDNF content in the hypothalamus after histamine treatment. We used immunohistochemical staining for histamine H1 receptors (H1-R) in BDNF neurons. BDNF-induced feeding suppression was partially attenuated in rats pre-treated with FMH or a CRF antagonist, and in H1KO mice. BDNF treatment increased CRF content and histamine turnover in the hypothalamus. Histamine increased BDNF content in the hypothalamus. Immunohistochemical analysis revealed that H1-Rs were expressed on BDNF neurons in the ventromedial nucleus of the hypothalamus. These results indicate that CRF and hypothalamic neuronal histamine mediate the suppressive effects of BDNF on feeding behavior and body weight. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text