Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches
| Autor: | Sekaran Saravanan, Zahra Sepehri, Mehnosh Toback, Hassan Marzban, Joseph W. Gordon, Kimia Sheikholeslami, Adel Rezaei Moghadam, Mohammad Hashemi, Jeffrey T. Wigle, Pooneh Mokarram, Anahita Masoom, Mansour Poorebrahim, Davinder S. Jassal, Dedmer Schaafsma, Saeid Ghavami, Michael P. Czubryt, Ian M.C. Dixon, Mohsen Akbari, Matthew R. Zeglinski, Haleh Rokni, Nima Khadem Mohtaram, Sanjiv Dhingra, Niketa Sareen, Sudharsana R. Ande, Pawan K. Singal |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cell signaling Cardiac fibrosis Cell Disease Regenerative Medicine 03 medical and health sciences Internal medicine medicine Animals Humans Myocardial infarction Heart Failure Transition (genetics) Tissue Engineering business.industry Myocardium medicine.disease 030104 developmental biology medicine.anatomical_structure Heart failure Cardiology Signal transduction business Signal Transduction |
| Zdroj: | Comprehensive Physiology |
| ISSN: | 2040-4603 |
| Popis: | Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell-based therapies and their possible use to avert the deteriorating nature of HF. © 2019 American Physiological Society. Compr Physiol 9:75-125, 2019. |
| Databáze: | OpenAIRE |
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