The additional diagnostic impact of positron emission tomography-computed tomography for lymph node metastasis from colorectal cancer: A prospective lymph node level analysis
| Autor: | Yoshinao Takano, Yukitoshi Todate, Toshihiko Takada, Hidetaka Kawamura, Hisashi Yamaguchi, Toshiyuki Saginoya, Katsuhiko Hashimoto, Koichi Hamada, Yujiro Nakayama, Michitaka Honda |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer Standardized uptake value Adenocarcinoma Sensitivity and Specificity Metastasis Fluorodeoxyglucose F18 Predictive Value of Tests Positron Emission Tomography Computed Tomography medicine Humans Prospective Studies Prospective cohort study Lymph node Aged Fluorodeoxyglucose business.industry General Medicine Swollen lymph nodes Middle Aged medicine.disease medicine.anatomical_structure Oncology Lymphatic Metastasis Surgery Female Radiology Lymph medicine.symptom Radiopharmaceuticals business Colorectal Neoplasms medicine.drug |
| Zdroj: | Journal of surgical oncologyREFERENCES. 124(7) |
| ISSN: | 1096-9098 |
| Popis: | Background We conducted a prospective study to determine the diagnostic performance of positron emission tomography-computed tomography (PET-CT) for lymph node metastasis in colorectal cancer patients. Methods We enrolled patients scheduled to receive curative surgery with lymph node dissection for colorectal adenocarcinoma who underwent contrast-enhanced abdominopelvic CT and PET-CT before surgery and who had primary lesions of cT2 or deeper. A radiologist determined the fluorodeoxyglucose uptake and the standardized uptake value (SUV) and metabolic volume (MV) to diagnose metastasis in cases with enlarged lymph nodes (≥7 mm long in minor diameter) on contrast-enhanced CT. Two gastrointestinal surgeons intraoperatively identified target lymph nodes to assess the association between images and pathological findings. The diagnostic performance (i.e., sensitivity, specificity, and positive and negative predictive values) for lymph node metastasis was determined using multilevel logistic modeling. Results A total of 205 colorectal cancer patients were enrolled from February 2018 to April 2020 and 194 patients were analyzed in this study. The sensitivity, specificity, and positive and negative predictive values of PET-CT were 15.3% (13.4%-17.5%), 100.0% (99.0%-100.0%), 100.0% (51.2%-100.0%), and 98.7% (98.5%-99.0%), respectively. Conclusion PET-CT is a useful modality for determining the presence of metastasis in swollen lymph nodes on contrast-enhanced CT in colorectal cancer patients. |
| Databáze: | OpenAIRE |
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