Effectiveness of inhaled hypertonic saline application for sputum induction to improve Mycobacterium tuberculosis identification in patients with pulmonary tuberculosis

Autor: Anton Tkachenko, Olena Borysova, Galyna Gumeniuk, Nekrasova Nataliya, Yurii Feshchenko, Mykhailo Kuzhko, Tetiana Butova, Mykola Gumeniuk, Dmytro Butov, Valeriy Myasoedov
Rok vydání: 2021
Předmět:
Zdroj: Wiener Medizinische Wochenschrift. 172:261-267
ISSN: 1563-258X
0043-5341
DOI: 10.1007/s10354-021-00871-5
Popis: This study assessed the effectiveness and diagnostic significance of hypertonic saline sputum induction for improving Mycobacterium tuberculosis (MTB) detection. A prospective, randomized, open, two-arm, comparative study on MTB identification effectiveness when using inhaled sodium chloride hypertonic solution was performed in patients diagnosed with pulmonary tuberculosis (TB). Patients were randomly assigned into two groups: group 1 (inhalation group) included patients who inhaled a 7% sodium chloride solution upon admission to the hospital, and group 2 (control group) coughed up their sputum as usual. For both groups, specimens were tested by bacterioscopic, bacteriological, and molecular genetic methods. Diagnostic chest radiography was performed for all participants. In this study, 644 patients (mean age 42.2 years; 151 women, 23.4%) were randomly divided into two groups. Low-quality sputum samples were observed in 7.4% of patients from the inhalation group and 28.8% in the control group (p
Databáze: OpenAIRE
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