Offline adaptive radiation therapy in the treatment of prostate cancer: a case study
| Autor: | Beverly Meyer, Evgenia Nigay, Nishele Lenards, Ashley Hunzeker, Heath Bonsall |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Urinary Bladder Planning target volume Rectum Adenocarcinoma Radiation Dosage 030218 nuclear medicine & medical imaging Disease course 03 medical and health sciences Prostate cancer 0302 clinical medicine Humans Medicine Radiology Nuclear Medicine and imaging Radiation treatment planning Organ Volume Radiological and Ultrasound Technology business.industry Radiotherapy Planning Computer-Assisted Prostatic Neoplasms Cancer Organ Size medicine.disease medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Radiology business Adaptive radiation therapy |
| Zdroj: | Medical Dosimetry. 44:1-6 |
| ISSN: | 0958-3947 |
| DOI: | 10.1016/j.meddos.2017.12.005 |
| Popis: | The purpose of this case study is to develop a method to account for the difference in the daily volumes in the bladder, rectum, and targets in prostate radiotherapy and to compare the predicted dose to the actual dose to these organs. Five patients, both prospectively and retrospectively, were selected from 2 different cancer centers, with a biopsy-confirmed diagnosis of prostate cancer. The patients' planning target volume (PTV) and organs at risk (OAR) were contoured on the computed tomography (CT) dataset using either Eclipse or Monaco treatment planning systems (TPSs). Cone-beam computed tomography (CBCT) scans were collected before each daily treatment and exported to MIM software for analysis. The automatically generated reports evaluated the organ volume changes, the actual dose received during a single fraction, and the projected dose to each organ at the completion of the treatment course via comparative cumulative dose-volume histograms (DVHs). Volume changes in the bladder and rectum can cause notable variations in the prescribed dose vs the actual dose received. MIM software was proven to have utility prospectively by tabulating daily dose and projecting final doses, potentially aiding physicians in decisions about the boost plans, thus making offline adaptive radiation therapy (ART) clinically manageable. |
| Databáze: | OpenAIRE |
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