YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis
| Autor: | Joachim Burman, Raili Raininko, Markus Axelsson, Clas Malmeström, Kaj Blennow, Henrik Zetterberg |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male musculoskeletal diseases 0301 basic medicine medicine.medical_specialty Pathology Neurology Immunology Lipopolysaccharide Receptors Gadolinium Inflammation CHI3L1 Cohort Studies Disability Evaluation 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Adipokines Lectins Glial Fibrillary Acidic Protein medicine Humans Immunology and Allergy Chitinase-3-Like Protein 1 Aged medicine.diagnostic_test business.industry Chronic Active Multiple sclerosis Brain Magnetic resonance imaging Middle Aged Multiple Sclerosis Chronic Progressive medicine.disease Magnetic Resonance Imaging 030104 developmental biology Astrocytes Biomarker (medicine) Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimmunology. 292:52-57 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2016.01.013 |
| Popis: | YKL-40 (CHI3L1) is a glycoprotein predominantly produced by reactive astrocytes in chronic active MS lesions, which are common in secondary progressive MS. In this study, YKL-40 was investigated in different stages of MS and in relation to MRI findings. YKL-40 levels in CSF samples from two independent patient cohorts of MS patients were determined with ELISA. CSF YKL-40 was increased in patients with active relapsing-remitting MS and correlated with the number of gadolinium enhancing lesions. Patients with secondary progressive MS had similar high levels of YKL-40, whereas not active relapsing-remitting MS patients had YKL-40 levels comparable to healthy controls. |
| Databáze: | OpenAIRE |
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