Spider-venom peptides as therapeutics
| Autor: | Sebastian Senff, Sing Yan Er, Jonas E. Jensen, Glenn F. King, Lachlan D. Rash, Natalie J. Saez, Volker Herzig |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Antifungal Agents genetic structures Spider Venoms Health Toxicology and Mutagenesis lcsh:Medicine Venom Review Pharmacology Biology Toxicology complex mixtures drugs drug discovery 03 medical and health sciences Antimalarials Erectile Dysfunction therapeutics Animals Humans cystine knot 030304 developmental biology 0303 health sciences Spider Analgesics Drug discovery spider venom lcsh:R 030302 biochemistry & molecular biology Cystine knot peptide 3. Good health Anti-Bacterial Agents Drug development Inhibitor cystine knot Cystine Knot Motifs Peptides Anti-Arrhythmia Agents |
| Zdroj: | Toxins Toxins, Vol 2, Iss 12, Pp 2851-2871 (2010) |
| ISSN: | 2072-6651 |
| Popis: | Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid subjugation of prey. Most spider venoms are dominated by disulfide-rich peptides that typically have high affinity and specificity for particular subtypes of ion channels and receptors. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides, making them a valuable resource for drug discovery. Here we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against a wide range of pathophysiological conditions including cardiovascular disorders, chronic pain, inflammation, and erectile dysfunction. |
| Databáze: | OpenAIRE |
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