Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats
| Autor: | Zhao Lin, Wu Yongbo, Chen Zhiqiang, Zhang Kai, Jin Daoqun, Guo Jie |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Potassium Channels Myocardial ischemia Myocardial Ischemia Ischemia Blood Pressure Rats Sprague-Dawley Heart Rate Katp channels Internal medicine Male rats Potassium Channel Blockers medicine Animals Hypoglycemic Agents cardiovascular diseases Receptor Beneficial effects Venoms business.industry General Medicine medicine.disease Rats Disease Models Animal Ventricular Fibrillation Ventricular fibrillation Tachycardia Ventricular cardiovascular system Cardiology Exenatide Hydroxy Acids Peptides Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Decanoic Acids |
| Zdroj: | Cardiology Journal. 20 |
| ISSN: | 1898-018X 1897-5593 |
| DOI: | 10.5603/cj.2013.0006 |
| Popis: | Glucagon-like peptide-1 and its receptor agonist-exendin-4 (Ex-4) have been shown to provide beneficial effects for cardiovascular diseases. This study investigated the effects of Ex-4 on ischemia-induced ventricular arrhythmias in rats.Anesthetized male rats were once treated with Ex-4 (5 μg/kg, i.v.) 1 h before ischemia in the absence and/or presence of 5-hydroxydecanoic acid (5-HD, 10 mg/kg, i.v., a specific inhibitor of mitochondrial ATP-sensitive potassium [KATP] channels) which were once injected 10 min before ischemia. And then subjected to ischemia for 30 min. Ventricular arrhythmias were assessed.During the 30-min ischemia, Ex-4 significantly reduced the incidence of ventricular fibrillation (VF) (p0.05). The duration of ventricular tachycardia (VT) + VF, the number of VT + VF episodes and the severity of arrhythmias were all significantly reduced by Ex-4 compared to those in myocardial ischemia group (p0.05 for all). Administration of 5-HD abolished the protective effects of Ex-4 on VF incidence, the duration of VT + VF, the number of VT + VF episodes and the severity of arrhythmias (p0.05 for all).This study suggested that Ex-4 could attenuate ischemia-induced ventricular arrhythmias in rats in which mitochondrial KATP channels may be involved. |
| Databáze: | OpenAIRE |
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