Imaging efficacy of a hepatocyte-selective polyiodinated triglyceride (DHOG-LE) for contrast-enhanced CT
| Autor: | Julie K. Doerr-stevens, Jamey P. Weichert, Marc A. Longino, Susan G. Chosy, B. Keegan Markhardt, Fred T. Lee, Yigal Greener, Anne Killam Bonneville, Cheryl Delaney, Cindy Burrascano, Douglas A. Bakan |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Enhanced ct media_common.quotation_subject Contrast Media Rats Sprague-Dawley chemistry.chemical_compound Medicine Contrast (vision) Animals Radiology Nuclear Medicine and imaging Lipoprotein metabolism Triglycerides media_common Triglyceride business.industry Liver Diseases Image Enhancement Imaging agent Rats medicine.anatomical_structure chemistry Liver Hepatocyte Hepatocytes Female Delivery system High incidence Radiology business Tomography X-Ray Computed |
| Zdroj: | Academic radiology. 9 |
| ISSN: | 1076-6332 |
| Popis: | RATIONALE AND OBJECTIVES In spite of the widespread use of water-soluble contrast media for computed tomography (CT), an organ-selective contrast agent is still seen as a desirable goal of radiology research (1–3). With its high incidence of primary and metastatic lesions and parenchymal pathology, the liver is one organ system that is likely to benefit from a targeted imaging agent. Although a number of attempts have been made toward developing a safe and effective hepatic CT contrast agent ( 4 –6), a commercially available product resulting from these efforts has yet to become available to clinicians. We have previously introduced and characterized a hepatocyte-selective CT contrast agent consisting of a polyiodinated triglyceride (ITG) in a lipid emulsion (LE) delivery system designed to participate in the naturally occurring lipoprotein metabolism pathways in the liver (7–9). Although this early formulation was effective in providing considerable hepatic opacification for prolonged periods of time after injection, the volumes required for achieving high levels of liver enhancement were potentially limiting. In an effort to reduce the volumes of material required for visualization of hepatic anatomy and pathology by CT, a series of high-concentration ITG-LE formulations was developed (10). The current work extends these improvements and characterizes the imaging efficacy of these high-concentration ITG-LE formulations in normal rats. |
| Databáze: | OpenAIRE |
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