Discriminant value of serum HBV DNA levels as predictors of liver fibrosis in chronic hepatitis B
| Autor: | Mohammed Q. Khan, Ahmed Helmy, Abdallah Al-Mdani, Mayssa Saadeh, Waleed Al-Hamoudi, Abdullah S. Alghamdi, Ahmed A. Al-Qahtani, Mohammed A. Babatin, A. Al-Akwaa, S. Almutharea, Faisal M. Sanai, T. Farah, Khalid I. Bzeizi, H. A. Al-Ashgar, Ayman A. Abdo |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Hepatitis B virus Viremia Gastroenterology Hepatitis B Chronic Sex Factors Fibrosis Virology Positive predicative value Internal medicine Biopsy Genotype medicine Humans Hepatitis B e Antigens Hepatology medicine.diagnostic_test business.industry Age Factors Histology Alanine Transaminase Bilirubin Hepatitis B Middle Aged medicine.disease Prognosis Infectious Diseases Immunology DNA Viral Female alpha-Fetoproteins Hepatic fibrosis business Biomarkers |
| Zdroj: | Journal of viral hepatitis. 18(7) |
| ISSN: | 1365-2893 |
| Popis: | Summary. Current guidelines recommend antiviral therapy in chronic hepatitis B (HBV) patients with significant histological disease. We aimed to compare histological fibrosis (METAVIR, ≥F2) in patients with HBV DNA ≥20 000 IU/mL vs≥2000 IU/mL and identify predictors of fibrosis. We performed prospective liver biopsies on 203 HBeAg-negative patients in four groups: Group I (n = 55): HBV DNA ≥20 000 IU/mL and persistently elevated alanine aminotransferase (ALT) levels (PEALT; >40 U/L); Group II (n = 34): HBV DNA ≥20 000 IU/mL and persistently normal ALT (PNALT); Group III (n = 40): HBV DNA |
| Databáze: | OpenAIRE |
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