Large Field of View Corneal Epithelium and Bowman's Layer Thickness Maps in Keratoconic and Healthy Eyes
| Autor: | Ruth Donner, Jan Lammer, Stephan Holzer, Gerald Schmidinger, Florian Beer, Michael Pircher, Christoph K. Hitzenberger, Andreas Gschließer, Niklas Pircher |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Keratoconus medicine.medical_specialty genetic structures 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Ophthalmology medicine Humans Bowman Membrane Bowman's layer 030304 developmental biology Corneal epithelium Mathematics 0303 health sciences Large field of view medicine.diagnostic_test Epithelium Corneal Healthy subjects Corneal Topography Organ Size medicine.disease Corneal topography Layer thickness Healthy Volunteers eye diseases Cross-Sectional Studies medicine.anatomical_structure ROC Curve 030221 ophthalmology & optometry Female sense organs Tomography Optical Coherence |
| Zdroj: | American Journal of Ophthalmology. 209:168-177 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2019.05.025 |
| Popis: | Purpose To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes. Design Cross-sectional study. Methods Setting: institutional. Study population: 47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye). Observation procedure: epithelium and Bowman's layer measurements were performed by using custom-designed polarization-sensitive optical coherence tomography (PS-OCT) with a conical scanning optics design. En face corneal ET and BLT maps with a diameter of 11 mm were computed. Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) and thickest sectors (maxET, maxBLT) were assessed. Ratios between thinnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior nasal quadrant (R2) were calculated (R1ET, R1BLT; R2ET, R2BLT). Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic power of statistically different parameters. Results In healthy eyes, smooth ET maps were observed. KC eyes showed a “doughnut pattern.” The BLT maps of healthy eyes had a smooth appearance, but highly irregular “moth”-like damage pattern could be observed in keratoconic eyes. Highest area under the curve values were found for the thinnest sector of the BLT map, the R1ET, and the thinnest sector of the ET map. Conclusions PS-OCT imaging enables the visualization of significant differences of the corneal epithelium and the Bowman's layer in en face maps covering almost the entire cornea. ET and BLT profiles could clearly show their diagnostic importance for the distinguishing of keratoconic eyes and healthy eyes. |
| Databáze: | OpenAIRE |
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