Hippocampal novelty activations in schizophrenia: Disease and medication effects
| Autor: | Ronald Chin, Carol A. Tamminga, Binu P. Thomas, Perry Mihalakos, Alison R. Preston, Anthony D. Wagner, Kenneth Youens |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis medicine.medical_treatment Hippocampus Hippocampal formation behavioral disciplines and activities Neuroimaging Cortex (anatomy) medicine Humans Psychiatry Antipsychotic Biological Psychiatry Functional Neuroimaging Novelty Recognition Psychology Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Schizophrenia Case-Control Studies Parahippocampal Gyrus Female Psychology Neuroscience Antipsychotic Agents |
| Zdroj: | Schizophrenia Research. 138:157-163 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2012.03.019 |
| Popis: | We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia. |
| Databáze: | OpenAIRE |
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