Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma
Autor: | Stephan Soeder, Alexander Olk, Tilman T. Rau, Thomas Aigner |
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Rok vydání: | 2006 |
Předmět: |
Male
Pathology medicine.medical_specialty Soft Tissue Neoplasm Cellular differentiation Mesenchymal cell differentiation Soft Tissue Neoplasms Biology Bone and Bones Pathology and Forensic Medicine Diagnosis Differential Mesenchymoma Periosteum medicine Adipocytes Humans Endochondral ossification Aged Ossification Heterotopic Mesenchymal stem cell Cell Differentiation Mesenchymal Stem Cells General Medicine Anatomy Lipoma medicine.disease stomatognathic diseases Cartilage Cell Transformation Neoplastic Thigh Stem cell |
Zdroj: | Annals of diagnostic pathology. 10(5) |
ISSN: | 1092-9134 |
Popis: | Lipomas are very common benign soft tissue neoplasms. They are usually slow-growing and may occur anywhere in the body. Mature cartilage and bone arising in a lipoma is a rare event and is mostly associated with a parosteal localization of the neoplasm. We describe a new case of osteochondrolipoma showing not only major adipocytic differentiation but also areas of fibrocytic and cartilaginous cell differentiation and bone formation (both endochondral and membranous). The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells. Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue. |
Databáze: | OpenAIRE |
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