Long term effectiveness of adjuvanted influenza A(H1N1)pdm09 vaccine in children
| Autor: | Malin Ryd Rinder, Åke Örtqvist, Joanna Nederby Öhd, Hans Lindblad, Johan Hamrin, Margareta Eriksson, Rutger Bennet |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Adolescent Antibodies Viral Seasonal influenza Influenza A Virus H1N1 Subtype Adjuvants Immunologic Pandemic Influenza Human medicine Odds Ratio Humans AS03 Child Pandemics Retrospective Studies Sweden General Veterinary General Immunology and Microbiology business.industry Influenza A Virus H3N2 Subtype Vaccination Public Health Environmental and Occupational Health virus diseases Infant Influenza a Odds ratio Hospitalization Infectious Diseases Influenza Vaccines Case-Control Studies Child Preschool Hospital admission Molecular Medicine Female Seasons business |
| Zdroj: | Vaccine. 33(22) |
| ISSN: | 1873-2518 |
| Popis: | Background Immunological studies have indicated that the effectiveness of AS03 adjuvanted monovalent influenza A(H1N1)pdm09 vaccine (Pandemrix®) may be of longer duration than what is seen for non-adjuvanted seasonal influenza vaccines. Sixty-nine percent of children 6 months–18 years of age in Stockholm County received at least one dose of Pandemrix® during the 2009 pandemic. We studied the effectiveness of the vaccine during the influenza seasons 2010–2011 and 2012–2013 in children hospitalized with virologically confirmed influenza. The season 2011–2012 was not included, since influenza A(H3N2) was the predominant circulating strain. Methods In a retrospective case-control study using a modified test-negative design we compared the percentage vaccinated with Pandemrix® among children diagnosed with influenza A(H1N1)pdm09 (cases), with that of those diagnosed with influenza A(H3N2) or influenza B (controls) during the two seasons. We excluded children born after July 1, 2009, since only children who were 6 months of age or older received the pandemic vaccine in October–December 2009. Results During the 2010–2011 season, 3/16 (19%) of children diagnosed with influenza A(H1N1)pdm09, vs. 32/41 (78%) of those with influenza A(H3N2) or influenza B had been vaccinated with Pandemrix® in 2009. The odds ratio, after adjustment for sex, age and underlying diseases, for becoming a case when vaccinated with Pandemrix® was 0.083 (95%CI 0.014, 0.36), corresponding to a VE of 91.7%. During the season 2012–2013, there was no difference between the two groups; 59% of children diagnosed with influenza A(H3N2)/B and 60% of those with influenza A(H1N1)pdm09 had been vaccinated with Pandemrix® in 2009. Conclusion The AS03 adjuvanted monovalent influenza A(H1N1) pdm09 vaccine (Pandemrix®) was effective in preventing hospital admission for influenza A(H1N1)pdm09 in children during at least two seasons. |
| Databáze: | OpenAIRE |
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