Investigation of simple, objective, and effective indicators for predicting acute paraquat poisoning outcomes
| Autor: | Michael G. Vaughn, Weiwei Liu, Namratha Gurram, Steven W. Howard, Zhengmin Qian, Chen Zhang, Echu Liu, Lenise A Cummings-Vaughn, Yimin Liu, Guang-Hui Dong, Jianyu Wang, Daire R Jansson, Yiwei Su |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Paraquat medicine.medical_specialty Health Toxicology and Mutagenesis Urinary system Toxicology 03 medical and health sciences chemistry.chemical_compound Leukocyte Count 0302 clinical medicine Internal medicine White blood cell medicine Humans 030212 general & internal medicine Retrospective Studies Creatinine Dose-Response Relationship Drug business.industry Herbicides Poisoning Public Health Environmental and Occupational Health Testing equipment Age Factors Middle Aged Prognosis PARAQUAT POISONING Acute toxicity Proteinuria Key factors medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Toxicity Female business |
| Zdroj: | Toxicology and industrial health. 36(6) |
| ISSN: | 1477-0393 |
| Popis: | Initial symptoms of paraquat (PQ) toxicity are often not obvious, and the lack of advanced testing equipment and medical conditions in the primary hospital make it difficult to provide early diagnosis and timely treatment. To explore simple, objective, and effective indicators of prognosis for primary clinicians, we retrospectively analyzed acute PQ poisoning in 190 patients admitted to our hospital from 2008 to 2017. Based on their condition at the time of discharge, patients were categorized into either the survival group ( n = 71) or the mortality group ( n = 119). Age, PQ ingested amount, urinary PQ, urinary protein, white blood cell (WBC), and serum creatinine (Cr) were the key factors associated with the prognosis for PQ poisoning. We identified specific diagnostic thresholds for these key indicators of PQ poisoning: PQ ingested amount (36.50 mL), urinary PQ (semiquantitative result “++”), urinary protein (semiquantitative result “±”), WBC (16.50 × 109/L), and serum Cr (102.10 µmol/L). Combining these five indicators to identify poisoning outcomes was considered objective, accurate, and convenient. When the combined score was |
| Databáze: | OpenAIRE |
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