Circulating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women
| Autor: | John H. Hipwell, Jeffrey M P Holly, Rachel Denholm, Elizabeth Folkerd, Isabel dos-Santos-Silva, Bianca De Stavola, Simon J. Doran, Martin O. Leach, David J. Hawkes, Mitch Dowsett |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Adolescent Epidemiology Physiology Dehydroepiandrosterone Estrone Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Sex hormone-binding globulin Sex Hormone-Binding Globulin medicine Humans Breast 030212 general & internal medicine Androstenedione biology business.industry medicine.disease Prolactin Parity Cross-Sectional Studies Oncology chemistry Growth Hormone 030220 oncology & carcinogenesis biology.protein Female business Body mass index Hormone |
| Zdroj: | Denholm, R, De Stavola, B L, Hipwell, J H, Doran, S J, Holly, J M P, Folkerd, E, Dowsett, M, Leach, M O, Hawkes, D J & Dos-Santos-Silva, I 2018, ' Circulating growth and sex hormone levels and breast tissue composition in young nulliparous women ', Cancer Epidemiology, Biomarkers and Prevention, vol. 27, no. 12, pp. 1500-1508 . https://doi.org/10.1158/1055-9965.EPI-18-0036 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-18-0036 |
| Popis: | Background: Endogenous hormones are associated with breast cancer risk, but little is known about their role on breast tissue composition, a strong risk predictor. This study aims to investigate the relationship between growth and sex hormone levels and breast tissue composition in young nulliparous women. Methods: A cross-sectional study of 415 young (age ∼21.5 years) nulliparous women from an English prebirth cohort underwent a MRI examination of their breasts to estimate percent-water (a proxy for mammographic percent density) and provided a blood sample to measure plasma levels of growth factors (insulin-like growth factor-I, insulin-like growth factor-II, insulin growth factor-binding protein-3, growth hormone) and, if not on hormonal contraception (n = 117) sex hormones (dehydroepiandrosterone, androstenedione, testosterone, estrone, estadiol, sex hormone–binding globulin, prolactin). Testosterone (n = 330) and sex hormone–binding globulin (n = 318) were also measured at age 15.5 years. Regression models were used to estimate the relative difference (RD) in percent-water associated with one SD increment in hormone levels. Results: Estradiol at age 21.5 and sex hormone–binding globulin at age 21.5 were positively associated with body mass index (BMI)-adjusted percent-water [RD (95% confidence interval (CI)): 3% (0%–7%) and 3% (1%–5%), respectively]. There was a positive nonlinear association between androstenedione at age 21.5 and percent-water. Insulin-like growth factor-I and growth hormone at age 21.5 were also positively associated with BMI-adjusted percent-water [RD (95% CI): 2% (0%–4%) and 4% (1%–7%), respectively]. Conclusions: The findings suggest that endogenous hormones affect breast tissue composition in young nulliparous women. Impact: The well-established associations of childhood growth and development with breast cancer risk may be partly mediated by the role of endogenous hormones on breast tissue composition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|