Norsesquiterpene Derivatives from the Roots ofLigularia fischeri
| Autor: | Yan-Ping Shi, Wen-Juan Zhang, Huan-Yang Qi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Molecular Structure Plant Extracts Stereochemistry Ligularia Chemical structure Organic Chemistry Ligularia fischeri Pharmaceutical Science Asteraceae Pharmacognosy Biology Sesquiterpene biology.organism_classification Plant Roots Platyphyllide Terpenoid Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Drug Discovery Molecular Medicine Sesquiterpenes Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Planta Medica. 76:159-164 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0029-1186036 |
| Popis: | Four new norsesquiterpene derivatives with various rare skeletons: 1 beta-hydroxy-6 alpha-isobutyryloxy-9-noreremophil-7(11),8(10)-dien-8(12)-olide ( 1), 1 beta-acetoxy-6 alpha-isobutyryloxy-9-noreremophil-7(11),8(10)-dien-8(12)-olide ( 2), ligularate ( 3) and 9-oxoplatyphyllide ( 4), as well as four known sesquiterpenes, platyphyllide ( 5), 1-hydroxyplatyphyllide ( 6), 1 alpha-chloro-6 beta-isobutyryloxy-9-oxo-10 beta-hydroxyfuranoeremophilane ( 7), and 1 alpha-chloro-6 beta-angeloyloxy-9-oxo-10 beta-hydroxyfuranoeremophilane ( 8), have been isolated from an extract of the dried roots of Ligularia fischeri (Compositae). The structures of the new compounds were established by spectroscopic methods including extensive 2D NMR techniques ( (1)H- (1)H COSY, HMQC, HMBC and (1)H- (1)H NOESY) and HR-ESI-MS. In addition, a plausible biosyntheticpathway for compounds 1, 2 and 3 is described. |
| Databáze: | OpenAIRE |
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