The evaluation of endometrial sulfate glycosaminoglycans in women with polycystic ovary syndrome
| Autor: | Regina Célia Teixeira Gomes, Mario Vicente Giordano, Edmund Chada Baracat, Luiz Augusto Giordano, Ricardo Simoes, Helena B. Nader, Mario Gáspare Giordano, José Maria Soares Júnior |
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| Rok vydání: | 2014 |
| Předmět: |
Infertility
Adult Risk medicine.medical_specialty Outpatient Clinics Hospital Endocrinology Diabetes and Metabolism media_common.quotation_subject Biopsy Endometrium Body Mass Index Menstruation Hospitals University chemistry.chemical_compound Young Adult Endocrinology Internal medicine Follicular phase medicine Humans Chondroitin sulfate Menstrual cycle media_common business.industry Chondroitin Sulfates Obstetrics and Gynecology Overweight medicine.disease Polycystic ovary Endometrial Neoplasms Up-Regulation medicine.anatomical_structure chemistry Follicular Phase Female Heparitin Sulfate business Body mass index Infertility Female Biomarkers Brazil Polycystic Ovary Syndrome |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 31(4) |
| ISSN: | 1473-0766 |
| Popis: | The aim of this study was to quantify the sulfated glycosaminoglycans in the endometria of women with polycystic ovary syndrome (PCOS). Of the 18 patients recruited for this study, 10 patients with PCOS comprised the PCOS group (PCOSG), and eight patients with regular and ovulatory menstrual cycles comprised the control group (CG). The clinical, biochemical, morphological and endometrial data from both groups were analyzed. Biopsies were performed during the proliferative phase of the menstrual cycle for the CG and during the persistent proliferative phase for the PCOSG (all women were amenorrheic). In the PCOSG, there was a significant increase in the endometrial concentration levels of heparan sulfate (p = 0.03), but no difference in the concentrations of chondroitin sulfate was determined between the two groups (p = 0.77). Period of time without menstruation (p = 0.001) and body mass index (BMI) (p = 0.04) correlated directly and positively with heparan sulfate concentration. There was no association between heparan sulfate levels and basal insulin values (p = 0.08). High levels of endometrial heparan sulfate in women with PCOS indicate an interference with maternal-fetal recognition, which contributes to infertility; thus, endometrial heparan sulfate may be a predictive marker of future neoplasia risk. |
| Databáze: | OpenAIRE |
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