Efficacy and safety of the apolipoprotein C-III inhibitor Volanesorsen: a systematic evaluation and meta-analysis

Autor:	Yonglang Cheng, Tongxi Li, Peng Tan, Yichao Du, Zhiwei Huang, Hao Shi, Tianying Cai, Yifan Chen, Wenguang Fu
Rok vydání:	2022
Předmět:	Hypertriglyceridemia Apolipoprotein C-III Endocrinology Endocrinology Diabetes and Metabolism Oligonucleotides Humans Triglycerides Randomized Controlled Trials as Topic
Zdroj:	Endocrine. 76:253-262
ISSN:	1559-0100
DOI:	10.1007/s12020-022-03025-8
Popis:	Familial celiac disease syndrome (FCS) is a form of hypertriglyceridemia (HTG) caused by the accumulation of celiac particles. Currently, volanesorsen is considered to be used to treat patients with FCS and HTG to improve symptoms. To evaluate the effect of volanesorsen on lipid metabolism in patients with FCS, we performed a systematic evaluation and meta-analysis.A systematic search of PubMed, Embase, ClinicalTrials.gov, and the Cochrane Library was conducted, and the bibliographies of original articles were checked manually. The quality of the studies was assessed using the Cochrane Risk of Bias tool.Four randomized, controlled trials involving 246 patients were analyzed in this study. Patients treated with volanesorsen showed (MD = -78.85%; 95% CI = -96.04 to -61.65, P = 0.67, I
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119557f1d2ad3a7f635817ee79f5b733 https://doi.org/10.1007/s12020-022-03025-8 Zobrazit plný text záznamu Full text from SpringerLink