Biphasic effects of Morus alba leaves green tea extract on mice in chronic forced swimming model
| Autor: | Prapawadee Puapairoj, Siriporn Tiamkao, Jintana Sattayasai |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Elevated plus maze Ratón medicine.medical_treatment Intraperitoneal injection Green tea extract Pharmacognosy Biology Motor Activity Mice Animal science Desipramine medicine Animals Maze Learning Swimming Pharmacology Traditional medicine Plant Extracts Motor coordination Plant Leaves Models Animal Morus Diazepam medicine.drug |
| Zdroj: | Phytotherapy research : PTR. 22(4) |
| ISSN: | 1099-1573 |
| Popis: | In this study, the effects of an aqueous extract of Morus alba leaves green tea (ME) on mouse behaviors (depression, anxiety, climbing activity and thermal response), muscle coordination and muscle strength were studied. Male IRC mice received a single intraperitoneal injection of either the ME, desipramine or diazepam. Thirty minutes after injection, the mice were tested in all experimental models. A significant antidepressant-like effect could be detected in the animals receiving either 100 or 200 mg/kg ME. The effect of 200 mg/kg ME in decreasing the immobility time was comparable to 10 mg/kg desipramine. With higher dose (1000 mg/kg), a significant increase in immobility time could be observed. In the elevated plus maze, no increase in time in the open arm could be observed in mice treated with ME at either 100 or 200 mg/kg. However, high doses of ME (500 or 1000 mg/kg) decreased both time in the open arm and the number of entries in the maze. No change in thermal response could be seen in mice treated with ME at doses up to 500 mg/kg, however, at 1000 mg/kg, the response time to heat was increased significantly. The ME at either 500 or 1000 mg/kg also decreased muscle coordination, strength and climbing activity significantly when compared with the control. This study suggests that ME possesses an antidepressant- without an anxiolytic-like effect, however, at high doses, the extract might show the sedative effect and alter other functions such as muscle strength, animal activity in the maze and pain response. Copyright © 2008 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text