Inhibition of clinical isolates of human cytomegalovirus and varicella zoster virus by PNU-183792, a 4-oxo-dihydroquinoline
| Autor: | Valerie A. Vaillancourt, Audris Huang, Roger J. Brideau, Mary L. Knechtel |
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| Rok vydání: | 2002 |
| Předmět: |
Ganciclovir
Human cytomegalovirus Herpesvirus 3 Human viruses Acyclovir Cytomegalovirus Viral Plaque Assay In Vitro Techniques Virus Replication medicine.disease_cause Antiviral Agents Virus Herpesviridae Cell Line Microbiology Betaherpesvirinae Virology Alphaherpesvirinae medicine Humans heterocyclic compounds Aciclovir biology business.industry Varicella zoster virus virus diseases biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Infectious Diseases Quinolines business medicine.drug |
| Zdroj: | Journal of Medical Virology. 68:234-236 |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.10193 |
| Popis: | The susceptibility of human cytomegalovirus (CMV) and varicella zoster virus (VZV) clinical isolates to PNU-183792, a 4-oxo-dihydroquinoline, was examined. The antiviral potency of PNU-183792, a non-nucleoside inhibitor, was compared to the licensed nucleoside inhibitors ganciclovir and acyclovir using plaque reduction and virus yield reduction assays. PNU-183792 was as potent against CMV as ganciclovir and was superior in potency to acyclovir against VZV. PNU-183792 represents a new class of non-nucleoside inhibitors of human herpesviruses. J. Med. Virol. 68: 234–236, 2002. © 2002 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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