Evaluation of Nivolumab for Ototoxic Effects: An Animal Study in Rats
| Autor: | Rauf Oğuzhan Kum, Ismail Guler, Muge Ozcan, Esra Özhamam Uçaryılmaz, Ihsan Kuzucu, Deniz Baklaci |
|---|---|
| Přispěvatelé: | Tıp Fakültesi |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Physiology 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Ototoxicity otorhinolaryngologic diseases medicine Animals Organ of Corti Saline Spiral ganglion Chemotherapy Dose-Response Relationship Drug business.industry Animal Study General Medicine medicine.disease lcsh:Otorhinolaryngology lcsh:RF1-547 Rats Disease Models Animal Nivolumab 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Personal computer Original Article Immunotherapy sense organs Brainstem Spiral Ganglion business |
| Zdroj: | Journal of International Advanced Otology, Vol 16, Iss 2, Pp 218-221 (2020) J Int Adv Otol |
| ISSN: | 2148-3817 1308-7649 |
| Popis: | Kuzucu, İhsan ( Aksaray, Yazar ) OBJECTIVES: The aim of this study was to assess whether nivolumab is ototoxic in rats and whether this ototoxicity is dose-dependent. MATERIALS AND METHODS: Twelve rats were divided into two groups: Group 1 (control group, 6 rats, 12 ears) received intraperitoneal saline for 14 days. Group 2 (study group, 6 rats, 12 ears) and received two doses of 3 mg/kg intraperitoneal nivolumab within 14 days. Auditory brainstem responses (ABRs) were performed preoperatively and 4 and 8 weeks postoperatively. We compared between the groups, morphologic appearance of spiral ganglion cells and organ of Corti and density of spiral ganglion cells (measured with conventional light microscope connected to a personal computer). RESULTS: In our control group, both spiral ganglion and organ of corti had a normal morphological appearance. In our study group, spiral ganglion cells had a normal morphological appearance. However, some sections showed possibly mild degenerative changes in the organ of corti. Of 12 samples in the study group, four had a significant loss of density of spiral ganglion cells compared to the control group. The baseline ABR thresholds did not significantly differ between the groups (p=0.713). There was no statistically significant difference between the groups regarding ABR thresholds at week 4 (p=0.347). However, a statistically significant difference was observed in the ABR thresholds at week 8 (p=0.045). CONCLUSION: The results of our study showed that nivolumab treatment has ototoxic effects. Based on our results, we recommend monitoring the changes in the hearing ability of chemotherapy patients. |
| Databáze: | OpenAIRE |
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