Salmon peptides limit obesity-associated metabolic disorders by modulating a gut-liver axis in vitamin D-deficient mice
| Autor: | Patricia L. Mitchell, Geneviève Pilon, Hélène Jacques, Jonathan Rolin, Laurent Bazinet, Marion Valle, Denis Richard, Marie-Claude Vohl, Roger S. McLeod, Claudia Gagnon, André Marette, Tom A. Gill, Loïc Hénault, Thibault V. Varin |
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| Rok vydání: | 2021 |
| Předmět: |
Vitamin
medicine.medical_specialty animal diseases Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Gut flora Diet High-Fat digestive system chemistry.chemical_compound Mice Endocrinology Insulin resistance Salmon Internal medicine Nonalcoholic fatty liver disease Medicine Glucose homeostasis Animals Obesity Vitamin D skin and connective tissue diseases Nutrition and Dietetics biology business.industry medicine.disease biology.organism_classification Mice Inbred C57BL chemistry Liver Homeostatic model assessment Metabolic syndrome Insulin Resistance business Peptides Lipoprotein |
| Zdroj: | Obesity (Silver Spring, Md.)REFERENCES. 29(10) |
| ISSN: | 1930-739X |
| Popis: | OBJECTIVE This study investigated the effects of a low-dose salmon peptide fraction (SPF) and vitamin D3 (VitD3 ) in obese and VitD3 -deficient mice at risk of metabolic syndrome (MetS). METHODS Obese and VitD3 -deficient low-density lipoprotein receptor (LDLr)-/- /apolipoprotein B100 (ApoB)100/100 mice were treated with high-fat high-sucrose diets, with 25% of dietary proteins replaced by SPF or a nonfish protein mix (MP). The SPF and MP groups received a VitD3 -deficient diet or a supplementation of 15,000 IU of VitD3 per kilogram of diet. Glucose homeostasis, atherosclerosis, nonalcoholic fatty liver disease, and gut health were assessed. RESULTS VitD3 supplementation increased plasma 25-hydroxyvitamin D to optimal status whereas the VitD3 -deficient diet maintained moderate deficiency. SPF-treated groups spent more energy and accumulated less visceral fat in association with an improved adipokine profile. SPF lowered homeostatic model assessment of insulin resistance compared with MP, suggesting that SPF can improve insulin sensitivity. SPF alone blunted hepatic and colonic inflammation, whereas VitD3 supplementation attenuated ileal inflammation. These effects were associated with changes in gut microbiota such as increased Mogibacterium and Muribaculaceae. CONCLUSIONS SPF treatment improves MetS by modulating hepatic and gut inflammation along with gut microbiota, suggesting that SPF operates through a gut-liver axis. VitD3 supplementation has limited influence on MetS in this model. |
| Databáze: | OpenAIRE |
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