Airway Inflammatory Responses Following Exposure to Occupational Agents
| Autor: | Simone Chaboillez, Philippe Prince, Catherine Lemière, Marie Hélène Dufour, Louis-Philippe Boulet |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Sputum Cytology Neutrophils Critical Care and Intensive Care Medicine Bronchial Provocation Tests Leukocyte Count Interquartile range Occupational Exposure Internal medicine Humans Medicine Asthma Occupational Retrospective Studies Asthma Analysis of Variance Inhalation business.industry Smoking Quebec Sputum food and beverages Eosinophil medicine.disease Respiratory Function Tests Eosinophils Molecular Weight medicine.anatomical_structure Endocrinology Immunology Regression Analysis Female Analysis of variance medicine.symptom Cardiology and Cardiovascular Medicine Airway business |
| Zdroj: | Chest. 141:1522-1527 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.11-1134 |
| Popis: | Background Airway inflammatory responses to specific inhalation challenges (SICs) with low-molecular-weight (LMW) and high-molecular-weight (HMW) agents have not been studied thoroughly. We assessed the changes in airway inflammatory cells following SIC in sensitized workers, and looked at the influence of various factors on the pattern of inflammatory responses to SIC. Methods Induced sputum analysis was performed in workers sensitized to LMW (n = 41) or HMW agents (n = 41) after a control day and after a positive SIC. Cell counts were compared with lung function and various clinical parameters. Results In the LMW group, eosinophils were increased following late asthmatic responses (median [interquartile range], 0.02 [0.04] × 10 6 cells/g vs 0.30 [0.80] × 10 6 cells/g and 1.0% [3.5] vs 8.9% [8.0], P 6 cells/g vs 2.3 [5.4] × 10 6 cells/g, P = .04). In the HMW group, eosinophil percentages increased both after early (1.0% [2.2] vs 5.5% [14.5], P = .003) and dual asthmatic responses (4.5% [3.7] vs 15.0% [13.7], P = .02). In the LMW group, the increases in neutrophils were higher in current smokers than in ex-smokers or nonsmokers. The length of exposure to the agent, tobacco use, and baseline percentage of eosinophils were independent predictors of the change in eosinophils, whereas age and baseline neutrophil percentage were predictors of the change in neutrophils. Conclusions This study confirms that eosinophils and neutrophils are increased after SIC, whatever the causal agent. The type of agent is not predictive of the inflammatory response to SIC. Smoking is associated with a more neutrophilic response after SIC with an LMW agent. |
| Databáze: | OpenAIRE |
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