Propofol does not affect the canine cardiac conduction system under autonomic blockade
| Autor: | Yasushi Nakaigawa, Soichiro Inoue, Ryousuke Ishii, Reiju Shimizu, Masaaki Satoh, Shigeo Ikeno, Satoshi Akazawa |
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| Rok vydání: | 1999 |
| Předmět: |
Atropine
medicine.medical_specialty Time Factors Refractory Period Electrophysiological Blood Pressure Propranolol Electrocardiography Dogs Heart Conduction System Heart Rate Internal medicine Bradycardia medicine Animals Infusions Intravenous Propofol Sinoatrial Node Vecuronium Bromide medicine.diagnostic_test business.industry Effective refractory period Parasympatholytics General Medicine Atrioventricular node Blockade Disease Models Animal Autonomic nervous system Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Atrioventricular Node Sympatholytics Cardiology Electrical conduction system of the heart business Anesthetics Intravenous Autonomic Nerve Block Follow-Up Studies Neuromuscular Nondepolarizing Agents medicine.drug |
| Zdroj: | Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 46:148-153 |
| ISSN: | 1496-8975 0832-610X |
| DOI: | 10.1007/bf03012549 |
| Popis: | To determine the effects of propofol on the cardiac conduction system in dogs with pharmacological autonomic blockade. In eight mongrel dogs receiving 6 mg·kg−1·hr−1 propofol and vecuronium under pharmacological autonomie blockade with atropine and propranolol the infusion rates of propofol were increased from 6, (baseline), to 12, 18 and 24 mg·kg−1·hr−1 at 60-min intervals. An electrophysiological study assessed sinus rate, sinus node recovery time, corrected sinus node recovery time, intraatrial conduction time, AV nodal effective refractory period, Wenckebach cycle length and AV conduction times. Electrocardiographical variables and arterial pressures were also measured. All measurements were repeated at 30 min after the beginning of each infusion of propofol. Propofol did not produce direct effects on the electrophysiological or electrocardiographical variables at any infusion rates. Heart rates did not change at higher infusion rates in the presence of decreases in arterial pressures. Propofol did not affect the cardiac conduction system in the presence of autonomic blockade. Thus, the direct cardiac effects of propofol do not play a causative role in the genesis of propofol-associated bradyarrhythmias. |
| Databáze: | OpenAIRE |
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