SARS-CoV-2 antibody seroprevalence and associated risk factors in an urban district in Cameroon

Autor: Josselin Guillebert, Jeanine Meke, Laura Ciaffi, Armel Tassegning, Desire Takou, Beat Stoll, Kenechukwu David Nwosu, Olivia Keiser, Franck Wanda, Erol Orel, Nicolas Ray, Eric Mimbe, Lucien Mama, Joseph Fokam, Eric Comte
Rok vydání: 2021
Předmět:
Male
Urban Population
COVID19
Epidemiology
Attack rate
General Physics and Astronomy
Seroprevalence
Antibodies
Viral
Risk Factors
Seroepidemiologic Studies
Medicine
Cameroon
Child
ddc:333.7-333.9
education.field_of_study
Multidisciplinary
biology
Geography
Age Factors
Middle Aged
Child
Preschool
Female
Viral spread
Antibody
Adult
Coronavirus disease 2019 (COVID-19)
Adolescent
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Science
Population
SARS-COV-2
Yaounde
General Biochemistry
Genetics and Molecular Biology
Article
Young Adult
Sex Factors
Urban district
Humans
education
ddc:613
Aged
business.industry
SARS-CoV-2
COVID-19
Diagnostic markers
General Chemistry
Patient Acceptance of Health Care
Immunoglobulin M
Viral infection
Immunoglobulin G
Africa
biology.protein
business
Demography
Zdroj: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature communications, Vol. 12 (2021) P. 5851
ISSN: 2041-1723
Popis: The extent of SARS-CoV-2 circulation in many African countries remains unclear, underlining the need for antibody sero-surveys to assess the cumulative attack rate. Here, we present the results of a cross-sectional sero-survey of a random sample of residents of a health district in Yaounde, Cameroon, conducted from October 14 to November 26, 2020. Among the 971 participants, the test-adjusted seroprevalence of anti-SARS-CoV-2 IgG antibodies was 29·2% (95% CI 24·3–34·1). This is about 322 times greater than the 0.09% nationwide attack rate implied by COVID-19 case counts at the time. Men, obese individuals and those living in large households were significantly more likely to be seropositive, and the majority (64·2% [58·7–69·4]) of seropositive individuals reported no symptoms. Despite the high seroprevalence, most of the population had not been infected with SARS-CoV-2, highlighting the importance of continued measures to control viral spread and quick vaccine deployment to protect the vulnerable.
Many African countries have reported relatively low numbers of COVID-19 cases but the true scale of the epidemic is unclear. Here, the authors conduct a population-based survey in a province of Cameroon and estimate 29% seroprevlance, >300 fold higher than the nationwide attack rate implied by case counts.
Databáze: OpenAIRE
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