INFLUENCE OF METYRAPONE ON PLASMA CONCENTRATIONS OF TESTOSTERONE AND ANDROSTENEDIONE IN MAN
| Autor: | K. O. Nilsson, B. Hökfelt |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Adult
Male Radioisotope Dilution Technique medicine.medical_specialty Time Factors Adolescent Hydrocortisone Endocrinology Diabetes and Metabolism Population Administration Oral Dexamethasone Basal (phylogenetics) Klinefelter Syndrome Endocrinology Addison Disease Internal medicine medicine Humans Endocrine system Testosterone Obesity Androstenedione education Aged 17-Hydroxycorticosteroids education.field_of_study Metyrapone Hypogonadism Body Weight General Medicine Middle Aged 17-Ketosteroids Cortisone Injections Intravenous Biological Assay Female Androstanes Gonadotropins medicine.drug Hormone |
| Zdroj: | Acta Endocrinologica. 68:576-584 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0680576 |
| Popis: | Metyrapone was administered either orally, 750 mg every four h, in a total of six doses, or intravenously 30 mg per kg body weight as a four h infusion. In three males with normal endocrine functions, metyrapone given orally or intravenously induced a fall in plasma testosterone and an elevation of androstenedione within 2–8 h. When metyrapone was administered to a patient given dexamethasone to suppress endogenous ACTH production, the androstenedione levels did not alter whereas the testosterone levels showed a slight, transient decrease. In two normal females metyrapone administration was followed by a marked increase in plasma androstenedione whereas testosterone showed only a minor, gradual increase. In one male patient with Addison's disease the basal plasma testosterone was normal whereas the level of androstenedione was low. Following metyrapone intravenously, there was a slight suppression of plasma testosterone but no change in the androstenedione concentration. In one patient with primary hypogonadism, two with secondary hypogonadism and two with Klinefelter's syndrome the plasma testosterone was low under basal conditions and did not change following metyrapone. Basal plasma androstenedione was within the range for normal males and increased markedly following metyrapone in all the cases. |
| Databáze: | OpenAIRE |
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