Incidence of prostate cancer in Sicily: results of a multicenter case-findings protocol
| Autor: | V. Cosentino, V. Gulino, A. Dammino, C. Aragona, G. Capizzi, G. Minaldi, P. Pepe, F. Amico, P. La Rosa, M. Gulletta, G. Raciti, Francesco Aragona, Q. Paola, S. Raffino, L. Orestano, Alberto Saita, S. Rotondo, C. Iurato, G. Azzarello, G. Rizza, F. Orestano, M. Motta, Dibenedetto G, A. Serrao, M. Barbera, Nicolosi D, A. Calarco |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology urologic and male genital diseases Palpation Prostate cancer Age Distribution Prostate Risk Factors Biopsy medicine Odds Ratio Prevalence Humans Sicily Aged Retrospective Studies Ultrasonography Gynecology medicine.diagnostic_test business.industry Incidence (epidemiology) Incidence Biopsy Needle Prostatic Neoplasms Retrospective cohort study Odds ratio Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen medicine.anatomical_structure business |
| Zdroj: | European urology. 47(5) |
| ISSN: | 0302-2838 |
| Popis: | To establish the incidence of prostate cancer (PCa) in Sicily in patients who entered an early detection protocol.From February 2002 to February 2004, 16,298 subjects aged 40-75 entered the protocol. Patients with suspicious DRE, PSA10 ng/ml, PSAor=2.5 ng/ml, from 2.6 to 4 ng/ml or from 4.1 to 10 ng/ml with F/T PSA ofor=15%,or=20% andor=25% respectively underwent needle biopsy according to an extensive protocol.3266 patients were eligible for biopsy; PSA wasor=4 in 12.7% andor=10 ng/ml in 63.9% of patients. A PCa was found in 1171 cases (36.9%) with a relationship between PCa incidence and PSA and age respectively (chi2-test, p0.0001); 51.8% of patients with PCa had a PSA10 and 8.8% a PSA4 ng/ml; 49% were clinically staged as T1c. The estimated odds ratios for each age group showed increased risk for PCa in the fourth decade with PSA between 2.6 and 4 ng/ml (12.5 times higher) and in the fifth decade with PSA between 4.1 and 10 ng/ml (6.2 times higher).Age and serum PSA levels are the major risk factors for PCa. On their basis it is possible to modulate the most suitable timing for early diagnosis in individual patients. |
| Databáze: | OpenAIRE |
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